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Fig. 6 | Cell & Bioscience

Fig. 6

From: The eukaryotic initiation factor 5A (eIF5A1), the molecule, mechanisms and recent insights into the pathophysiological roles

Fig. 6

Autophagy control by eIF5A. The hypusination of eIF5A is a prerequisite for the translation of TFEB and ATG3, two tri-prolines containing proteins essential in the autophagy pathway. (1) TFEB: the member of the basic helix-loop-helix leucine-zipper family of transcription factors, is a master regulator of autophagic flux via inducing lysosome biogenesis and promoting autophagosome formation as well as its fusion with lysosome. (2) Atg3: an E2-like enzyme that catalyzes the conjugation of Atg8 and phosphatidylethanolamine (PE). The Atg8-PE conjugate is essential for the maturation of autophagosomes

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Cell & Bioscience

ISSN: 2045-3701

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