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Fig. 5 | Cell & Bioscience

Fig. 5

From: The eukaryotic initiation factor 5A (eIF5A1), the molecule, mechanisms and recent insights into the pathophysiological roles

Fig. 5

Role of eIF5A in brain aging. Hypusination of eIF5A represents a link between spermidine and its protective effect against age related senescence in the nervous system. a In fly, dietary spermidine supplementation maintains polyamine brain concentration and eIF5A hypusination to juvenile levels, which limits brain aging by preventing mitochondrial dysfunction. b In mammals, enhanced dietary spermidine intake improves eIF5A hypusination in aging brain which favors cognitive functions through autophagy and mitochondrial activity. Conversely, inhibition of eIF5A hypusination leads to mitochondrial dysfunction and to alteration of cognitive functions

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Cell & Bioscience

ISSN: 2045-3701

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