Fig. 2

Role of eIF5A in phenotype acquisition of immune cells. a Polyamine-hypusine alteration caused epigenetic remodeling due to alterations in histone acetylation and tricarboxylic acid (TCA) cycle rewiring. Thus, polyamine metabolism is essential for maintaining specificity of T cell gene expression to drive T cell subset fidelity. b Macrophage polarizations are highly dependent of energy metabolism, glycolysis allowing classical activation of MΦ to M1 pro-inflammatory macrophages and oxidative phosphorylation (OXPHOS) is required to alternative activation in M2 anti-inflammatory macrophages. Hypusination of eIF5A, through control of mitochondrial protein expression, is mandatory for alternative activation of macrophages