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Fig. 9 | Cell & Bioscience

Fig. 9

From: Exosomes originating from infection with the cytoplasmic single-stranded RNA virus Rift Valley fever virus (RVFV) protect recipient cells by inducing RIG-I mediated IFN-B response that leads to activation of autophagy

Fig. 9

Proposed Model of Exosomal Function During RVFV Infection. EXi-RVFV released by infected cells travel to local and distant target naïve cells. Following entry, viral RNA genome carried by EXi-RVFV are released first, and specific viral RNA sequence(s) that form appropriate dsRNA panhandle structures induce RIG-I. The activation of RIG-I leads to induction of IFN-B that is subsequently released to elicit both autocrine and paracrine IFN responses that involves activation of autophagy. Increased autophagy leads to encapsulation of virus particles that could reach and enter the cell at a later stage, eliminating them through autolysosomes to result in a significant decrease in viral replication, and therefore propagation

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Cell & Bioscience

ISSN: 2045-3701

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