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Fig. 3 | Cell & Bioscience

Fig. 3

From: Exosomes originating from infection with the cytoplasmic single-stranded RNA virus Rift Valley fever virus (RVFV) protect recipient cells by inducing RIG-I mediated IFN-B response that leads to activation of autophagy

Fig. 3

Pre-treatment of Naïve Recipient Human Lung Epithelial Cells with EXi-RVFV Significantly Reduces Viral Replication in the Cells during Subsequent Infection. A Naïve HSAECs were treated with either EXu or EXi-RVFV and cell viability was measured using acridine orange/propidium iodide (AO/PI) stain at 24 and 48 h. Mean values ± SEM from three biological replicates are shown. B Viral loads in naïve HSAECs that had been pretreated with either EXu or EXi-RVFV and subsequently infected with RVFV were compared based on genetic copy equivalent (RT-qPCR) measurements. Both the 6 h p.i. and the 24 h p.i. time points were analyzed. For each treatment condition and time point assayed, mean values ± SEM from three biological replicates are shown. **P ≤ 0.01; ***P ≤ 0.005; ****P ≤ 0.0005

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Cell & Bioscience

ISSN: 2045-3701

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