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Fig. 10 | Cell & Bioscience

Fig. 10

From: SIRT6 inhibition delays peripheral nerve recovery by suppressing migration, phagocytosis and M2-polarization of macrophages

Fig. 10

SIRT6 activation shifts the macrophages from M1 to M2 phenotype. A The cultured macrophages were stimulated with 150 μM UBCS039, or LPS and IFN-γ, and UBCS039 was added into culture medium in presence of LPS and IFN-γ for 24 h. B Cellular morphology of macrophages after stimulation. Scale bar: 50 µm. C Western blots of iNOS, NF-κB and Arg-1. D Quantification of iNOS, NF-κB and Arg-1 protein levels in macrophages. The protein levels were normalized with β-actin. *P  < 0.05. E Schematic diagram of how SIRT6 regulates M1/M2 polarization in macrophages

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