Fig. 10From: SIRT6 inhibition delays peripheral nerve recovery by suppressing migration, phagocytosis and M2-polarization of macrophagesSIRT6 activation shifts the macrophages from M1 to M2 phenotype. A The cultured macrophages were stimulated with 150 μM UBCS039, or LPS and IFN-γ, and UBCS039 was added into culture medium in presence of LPS and IFN-γ for 24 h. B Cellular morphology of macrophages after stimulation. Scale bar: 50 µm. C Western blots of iNOS, NF-κB and Arg-1. D Quantification of iNOS, NF-κB and Arg-1 protein levels in macrophages. The protein levels were normalized with β-actin. *P  < 0.05. E Schematic diagram of how SIRT6 regulates M1/M2 polarization in macrophagesBack to article page