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Table 3 Association of a polygenic risk score for LOY predisposition (LOY-PRS) as a categorical variable (low, middle, high), with LOY measured in 5131 men

From: A polygenic risk score predicts mosaic loss of chromosome Y in circulating blood cells

 

OR (95% CI)*

p-value*

LOY low risk PRS

Reference

 

LOY middle risk PRS

2.23 (1.83–2.73)

 < 0.0001

LOY high risk PRS

5.05 (4.05; 6.32)

 < 0.0001

Age, (years)

1.12 (1.09; 1.12)

 < 0.0001

Smoking

  

 Never/Former

Reference

 

 Current

2.00 (1.44; 2.76)

 < 0.0001

Alcohol

  

 Never/Former

Reference

 

 Current

1.2 (1.00; 1.45)

0.05

  1. * OR: odds ratios and p-values assessed using logistic regression. The LOY-PRS group define as: low < 20%, Middle 30–60% and high > 80% PRS
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Cell & Bioscience

ISSN: 2045-3701

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