Fig. 4
From: The regulatory mechanism of neutrophil extracellular traps in cancer biological behavior
NETs promote coagulation and cancer-associated thrombosis. NETs provide a scaffold for platelets and tumor-derived EVs. Exposure of PS on platelets and endothelial cells that are induced by NETs promotes coagulation and cancer-associated thrombosis. EVs, which recruited by NETs, lead to a prothrombotic state. TF, which is derived from EVs or NETs, can promote cancer-associated thrombosis by initiating extrinsic coagulation. The factor XII, which can trigger the contact system, is associated with the level of NETs. However, the mechanisms by which NETs drive factor XII- and cancer-associated thrombosis need next studies