Fig. 3
From: The regulatory mechanism of neutrophil extracellular traps in cancer biological behavior
Molecular mechanisms of NETs in tumor metastasis. HMGB1, which is released by NETs, can facilitate tumor metastasis by the increased expression of EMT-associated genes, ZEB1 and Snail. In addition to EMT, NETs can also regulate expression of COX-2 and MAP to induce tumor migration. In human breast cancer cells, NET DNA binds to CCDC25 and induces an ILK-β-PARVIN-RAC1-CDC42 cascade, resulting in the metastasis of cancer cells. TSP-1 can be degraded by NETs to eliminate its inhibitory effect on tumor migration