Skip to main content
Fig. 5 | Cell & Bioscience

Fig. 5

From: Single-cell RNA-sequencing reveals distinct immune cell subsets and signaling pathways in IgA nephropathy

Fig. 5

scRNA-seq identified DE genes of classical monocytes closely associated with the clinical parameters of IgAN. A UMAP illustration of refined monocyte cell clusters from CTRL and IgAN annotated by their marker genes: cMono-0 (Red circles), cMono-1 (Green circles), cMono-2 (Blue circles), cMono-3 (Purple circles). B Heatmap of the marker genes contributed from each classical monocyte subsets. C Individual UMAP illustration of classical monocytes by cells of origin. D Statistical analysis of each classical monocyte subset between CTRL and IgAN. CTRL n = 6; IgAN n = 10; Mean ± SEM. E Volcano plot showing both up- (Red circles) and down-regulated (Blue circles) DE genes in IgAN classical monocytes compared with that in CTRL. F, G Representative violin plots of newly discovered (F) and previously reported (G) DEGs in IgAN classical monocytes. H Heatmap of the Spearman correlation of IgAN clinical parameters with the expression levels of up- (Red circles) and down-regulated (Blue circles) DEGs in classical monocytes. Red and blue boxes indicate positive and negative correlations, respectively. *p < 0.05; **p < 0.01

Back to article page