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Table 3 GAB2 methylation values (%) for each CpG unit among four groups in liver and adipose tissues of mice

From: Effect of exercise and diet intervention in NAFLD and NASH via GAB2 methylation

CpGs

Liver (Methylation%)

Adipose (Methylation%)

MCD

LFD

HFD

ELFD

P1

P2

MCD

LFD

HFD

ELFD

P3

P4

CpG_1.2

0.00

3.80

4.00

29.50

0.043

0.114

1.71

1.00

1.83

1.86

0.327

0.620

CpG_3

0.00

0.40

5.33

1.00

0.075

0.686

2.29

3.67

0.33

2.57

0.288

1.000

CpG_5

8.00

4.20

10.17

0.00

0.459

0.114

0.43

1.89

5.83

1.00

0.754

0.318

CpG_6.7

9.25

14.00

15.00

4.00

0.522

0.400

8.71

18.33

5.67

2.57

0.044

0.001

CpG_8

2.25

3.25

5.67

31.50

0.812

0.200

1.14

1.88

4.33

1.43

0.360

1.000

CpG_9

6.25

8.00

0.83

6.00

0.054

0.686

1.14

4.11

2.17

5.00

0.216

0.073

CpG_10.11.12

3.75

9.00

6.17

8.00

0.498

0.629

3.14

5.33

3.00

8.43

0.184

0.002

CpG_13.14.15

2.50

3.80

2.67

18.25

0.400

0.114

2.29

3.11

2.33

6.29

0.842

0.001

CpG_16.17

3.00

3.00

3.00

20.75

0.608

0.057

3.43

3.44

2.33

6.86

0.303

0.053

CpG_18.19

2.00

2.60

3.50

15.75

0.427

0.029

2.00

1.44

2.17

6.57

0.203

0.001

CpG_20.21

3.75

2.60

9.83

10.00

0.342

0.200

0.71

3.67

7.67

1.86

0.598

0.073

CpG_23.24

3.00

4.00

3.33

6.25

0.788

0.343

3.29

3.78

2.83

4.57

0.466

0.902

CpG_25.26.27.28

7.25

10.40

10.17

13.00

0.134

0.200

8.86

10.33

10.00

11.29

0.359

0.017

CpG_30

2.25

3.00

3.50

6.75

0.918

0.343

2.57

2.67

1.83

9.86

0.155

0.001

CpG_31

5.25

1.60

5.17

3.50

0.308

0.486

2.71

4.78

2.86

10.29

0.670

0.001

CpG_33

0.75

1.20

2.33

0.50

0.386

0.486

1.43

1.56

0.83

3.57

0.225

0.026

Average CpG

3.70

4.68

5.69

12.13

0.513

0.057

2.87

4.59

3.03

5.25

0.048

0.001

  1. P1 and P3 indicate p value among MCD, LFD and HFD in liver and adipose, respectively. P2 and P4 indicate p value between MCD and ELFD in liver and adipose, respectively
  2. CpGs: cytosine-guanine dinucleotides; GAB2: GRB2 associated binding protein 2; ELFD: exercise plus low fat diet; HFD: high fat diet; LFD: low fat diet; MCD: methionine choline deficient