Effect of exercise and diet intervention in NAFLD and NASH via GAB2 methylation

Cell & Bioscience

Table 2 Specific information on CpGs of promoters in GAB2 and HRAS in NAFLD patients after diet and exercise plus diet intervention

		Pre_average methylation	Post_average methylation	Δβ	p value	q value	Chromosome	Feature	CGI
LCD	GAB2
	cg02802179	0.982	0.934	− 0.048	0.007	0.020	11	TSS1500	Opensea
	cg04116507	0.880	0.928	0.048	0.009	0.025	11	5’UTR	Opensea
	cg13087871	0.630	0.514	− 0.117	0.012	0.031	11	5’UTR	Opensea
	HRAS
	cg05798318	0.139	0.242	0.103	0.005	0.016	11	TSS1500	Island
	cg02606081	0.100	0.146	0.046	0.011	0.029	11	TSS1500	Island
	cg05508592	0.054	0.070	0.016	0.018	0.043	11	5'UTR	Island
	cg06920740	0.076	0.064	− 0.012	0.019	0.045	11	5'UTR	Island
ELCD	GAB2
	cg22494377	0.934	0.876	− 0.058	0.005	0.016	11	5’UTR	Opensea
	cg13087871	0.657	0.528	− 0.129	0.011	0.030	11	5’UTR	Opensea
	HRAS
	cg05798318	0.244	0.372	0.128	0.014	0.036	11	TSS1500	Island

CGI: cytosine-guanine dinucleotide island; CpGs: cytosine-guanine dinucleotides; GAB2: GRB2 associated binding protein 2; NAFLD: nonalcoholic fatty liver disease; HRAS: HRas proto-oncogene; ELCD: exercise plus low carbohydrate diet; LCD: low carbohydrate diet; TSS1500: transcription start site 1500 base pair; 5’UTR: 5 prime untranslated regions

ISSN: 2045-3701