Fig. 1
From: Role of FoxO transcription factors in aging and age-related metabolic and neurodegenerative diseases
Structural domains of FoxO proteins across species. Members in FoxO family share a highly conserved forkhead DNA-binding domain (DBD), a nuclear localization signal (NLS), one or two nuclear export signal (NES), and a transactivation domain (TAD). FoxO6 does not have a functional NES. The positions of Akt phosphorylation sites are indicated by circles. The first two phosphorylation sites also serve as binding motifs for 14-3-3 protein [2,3,4,5,6,7,8])