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Fig. 6 | Cell & Bioscience

Fig. 6

From: PRCC reduces the sensitivity of cancer cells to DNA damage by inhibiting JNK and ATM/ATR pathways and results in a poor prognosis in hepatocellular carcinoma

Fig. 6

PRCC reduced the sensitivity of HCC cells to DNA damage and led to high ITH and short OS by inhibiting the JNK/ATM/ATR/ATF2 axis. a Expression of the DNA damage and repair related proteins examined by Western blot. The numbers below the bands were the ratios of the gray values of each indicator to that of GAPDH. b Expression of p-JNK/JNK and p-P38/P38 by Western blot. The numbers below the bands were the ratios of the gray values of p-JNK to that of JNK, and the gray values of p-P38 to that of P38. c Schematic diagram of the mechanism of PRCC in HCC cells. d The patients with abnormally high expression of PRCC had high MATH (or ITH) (P < 0.05). e The results of survival analysis showed that high MATH (or ITH) corresponded to short overall survival (P < 0.05)

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Cell & Bioscience

ISSN: 2045-3701

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