Mitochondrial dysfunction, UPRmt signaling, and targeted therapy in metastasis tumor

Cell & Bioscience

Table 3 Drugs inhibiting UPR^mt-mediated chaperones and proteases pathway in carcinoma cells

Drug	Carcinoma type	Inhibition pathway	References
Geldanamycin	Metastatic cells, breast, lung carcinoma	Inhibition of CHOP/HIF1-α	[135]
Gamitrinib	Oral, breast, hepatocellular	Inhibiting sirt3/7-tnf receptor-associated protein-1 (trap-1)	[136, 137]
LCS-1	Lung carcinoma cell, neck, head carcinoma	Inhibition of chop	[138, 139]
The cupric derivatives with diethyl diethyldithiocarbamate and ATN-224 tetrathiomolybdate	Lung carcinoma cell	Inhibited the sirt7/sod1 pathway	[140, 141]
Bortezomib/PS341	Myeloma, laryngeal cancer, and lymphoma	Inhibition of sirt7/26 s proteasome	[143]
Disulfiram	Oral and pharyngeal tumor cells	CHOP	[145]
Celecoxib	Oral, head, neck, colorectal carcinoma	CHOP/BNIP3	[146]
Dasatinib	Myelogenous leukemia, lymphoblastic leukemia, head and neck carcinoma	Inhibition of CHOP and AMPK pathway	[147, 148]

ISSN: 2045-3701