Table 2 Mitochondrial dysfunction and pathway of UPR^mt in carcinoma cells

Lung, breast, glioma cells

HSP60, HSP10 stress protein

CHOP

[23, 24]

Glioblastoma, melanoma, prostate carcinoma cells

Gene expression of Egr-1, BCL-2, and MCL1

CHOP/ATF

[39]

Lung, Pancreatic, Breast, Glioma

ATF-5

CHOP

[40,41,42]

Breast cancer

PARP inhibition, NRF1 with SIRT7

CHOP/SIRT3

[45, 46]

Hepatic, gastrointestinal, breast carcinoma

Alteration in the mtDNA copy

CHOP/SIRT3/PINK

[49,50,51,52]

Breast Carcinoma

ROS production through ND6 gene mutation, upregulation of VEGF

PINK/JNK/HIF-α stabilization

[55]

Breast cancer

Defect in mitochondrial gene complex I

SIRT3/CHOP

[56]

Oral, breast cancer

NQO1 deficiency,4977 gene deletion

SOD/NRF1

[57,58,59,60]

Metastatic cells

Downregulation of NDUFV1

NRF1

[61]

Breast cancer

mtDNA mutation

CHOP/SOD/NRF1

[64]

Lung adenocarcinoma

mtDNA ND6 gene mutation

CHOP/SOD/NRF1

[65]

Renal, neuroblastoma, glioma

FH, SDH, IDH enzyme mutation

CHOP/NRF1

[66,67,68]

Head, neck, oral, breast

Downregulation of OGG1-2a

SIRT3

[69, 70]

Breast, Renal and Pancreatic carcinoma

PINK1/BCl-2, BNIp3/NIX overexpression

SIRT3/CHOP/NRF1

[71]

Hepatocellular carcinoma cells

ROS production

NRF2/PGC 1a/JNK

[73,74,75]

Fibrosarcoma (mesenchymal tumor)

Calcium dysfunction, Inhibition of NF-κB, Ros production

CHOP/EGR1/JNK/MAPK

[76, 77]

Breast carcinoma cells

OMI/HTRA2,NRF1

SIRT3

[78, 79]

Fibrosarcoma, colorectal adenocarcinoma

Knockdown of ATF4, ATF4 expression inhibition through GCN2 activation

CHOP/SIRT3

[81, 82]

Glioblastoma, pancreatic cancer

Inhibition of ATF5

CHOP

[84]

Head, neck cancer

SIRT3/FOXO3a/SOD2

CHOP/SIRT3

[85]

Myeloid leukemia

Inhibition of Bcl2, knockdown of SDHB

NFR1/2

[86]

Breast cancer

ROS production

NFR1/2/CHOP

[10, 87]

Breast cancer

Depletion of OMA1 increased gene expression ki67

CHOP/NFR1/PINK

[88]

Myeloid leukemia metastatic cancer

Inhibition of ClpP

CHOP

[89, 90]

Breast cancer

Overexpression of Her2

CHOP

[91]

Breast cancer

Inhibition of JNK2

CHOP

[34]

Bone carcinoma

ND3 mutation

CHOP/SIRT3

[92]

Breast carcinoma

ROS production, SOD1/2

SIRT3

[93]

Glioblastoma

BNIP3 upregulation

CHOP/SIRT3/NFR1/2

[94]

Lung carcinoma

Elevated fascin

CHOP

[96]

Breast

Knockdown of BRCA1/2

SOD/NFR1

[97, 98]

Glioblastoma

Downregulation of PINK, HIF-1α stabilization

CHOP/PINK/NRF

[99]

Breast, pancreatic cancer

Knockdown of BNIP3

CHOP/NRF1/SOD

[100,101,102]

Breast, neck, colorectal, head carcinoma

Upregulation CAIX, HIF 1-α stabilization

CHOP/SIRT3

[103, 104]

Gastric, breast, colorectal carcinoma

ROS production, HIF 1-α stabilization

SIRT3

[105]

Pancreatic ductal adenocarcinoma

ROS production, HIF 1-α deletion

PINK1/Parkin

[106]

Ovarian, lung, colorectal carcinoma cells

BNIP3/NIX downregulates SPHK1

CHOP/SIRT3

[107, 108]

Breast cancer

Overexpression of MCU

Calcium/CHOP

[109, 110]

Liver cancer lining

Knockdown of PDK1

CHOP/NRF1/2

[111]

Hepatocellular carcinoma

Upregulation of DRp1, mitochondrial fission

CHOP/NRF1

[112]

Renal carcinoma cells

2-HG, de-methylation of histone

CHOP/PINK

[117,118,119]

Renal and colorectal carcinoma cells

Overexpression of FGF21, GDF15

CHOP/NFR1

[121, 122]