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Fig. 5 | Cell & Bioscience

Fig. 5

From: Current knowledge and challenges associated with targeted delivery of neurotrophic factors into the central nervous system: focus on available approaches

Fig. 5

MANF and CDNF signaling pathways. Both MANF and CDNF regulate cell activity during ER stress and UPR function. MANF initiates PKC signaling and impedes degeneration of Purkinje cells. The MANF/STAT3 and MANF/ERK1/2 adjust the migration and differentiation of cells. The NF-κB signaling is regulated via MANF to control the inflammation. CDNF inhibits JNK in reducing inflammation via downregulation of the PGE2 and IL-1β. Further, CDNF increases the Bcl-2/Bax ratio and reduces apoptosis

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Cell & Bioscience

ISSN: 2045-3701

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