Skip to main content
Fig. 2 | Cell & Bioscience

Fig. 2

From: Current knowledge and challenges associated with targeted delivery of neurotrophic factors into the central nervous system: focus on available approaches

Fig. 2

GDNF/RET signaling pathway. The GDNF/GFRα1 complex triggers the intracellular signaling pathway through phosphorylation of the RET tyrosine kinase receptor. The RET in turn activates Src family tyrosine kinase. The activation of Src triggers the Raf/Ras/MAPK cascade leading to proliferation, differentiation, and neuritogenesis. The Raf/Ras/ERK/CREB pathway in collaboration with PI3K/AKT axis induces cell survival in the brain context. In the GDNF/NCAM pathway, the GDNF/GFRα1 complex recruits the NCAM which in subset activates the Fyn/FAK complex. These changes contribute to axonal expansion

Back to article page