Skip to main content
Fig. 1 | Cell & Bioscience

Fig. 1

From: Current knowledge and challenges associated with targeted delivery of neurotrophic factors into the central nervous system: focus on available approaches

Fig. 1

Different stem cells and cells can be utilized as a vehicle for neurotrophic factor (NTF) delivery. Mesenchymal stem cells (MSCs) can be utilized as three different cells: the naïve MSCs can secrete NTF when transplanted in the CNS of rodents. The MSCs can be engineered to overexpress a kind of NTF or can overexpress a variety of NTF when is differentiated to Neurotrophic factor secreting cells (NTF-SCs). Neural stem cells (NSCs) can be transplanted as naïve NSCs or NTF overexpressed NSCs for NTF delivery. The immune cells like macrophages can be engineered to overexpress NTF. Different viruses were utilized as vehicles for NTF delivery. AdV; Adenovirus, AAV; Adeno-associated virus, LV; Lentivirus. Different biomaterials, both natural and synthetic ones were utilized for NTF delivery into the CNS. HAMC; hyaluronan/methylcellulose, PEG; poly (ethylene glycol), PNIPAAm; Poly(N-isopropylacrylamide), DCH; Amphiphilic diblock copolypeptide hydrogel, HyStem; HyStem®-C hydrogel, PLGA; Poly (lactic-co-glycolic acid)

Back to article page

Cell & Bioscience

ISSN: 2045-3701

Contact us