Fig. 4
From: Metabolic reprogramming and metabolic sensors in KSHV-induced cancers and KSHV infection
KSHV hijacks cellular metabolic sensors. KSHV-encoded vGPCR and glycoprotein K1 activate the mTORC1 signaling pathway through the PI3K-AKT cascade; KSHV vPK mimics the cellular S6K1 and directly phosphorylates S6, resulting in mTORC1 activation; KSHV miRNA-K1 and -K4 activate mTORC1 by downregulating CASTOR1; KSHV glycoprotein K1 directly interacts with and activates AMPK in nutrients-stressed condition; and KSHV activates AMPK by upregulating SIRT1