Fig. 2
From: Metabolic reprogramming and metabolic sensors in KSHV-induced cancers and KSHV infection
The glutaminolysis is upregulated in KSHV-infected and -transformed cells. KSHV promotes glutamine uptake by upregulating glutamine transporter SLC1A5; KSHV enhances glutaminolysis by upregulating several glutaminolytic enzymes including GLS1/2, GLUD1 and GOT2; KSHV Kaposin A upregulates mGluR1 to promote glutamate secretion while KSHV mediated upregulation of ASS1 via miRNAs and iNOS accelerates the citrulline-NO cycle leading to STAT3 activation