Fig. 1
From: Metabolic reprogramming and metabolic sensors in KSHV-induced cancers and KSHV infection
The glycolytic pathway in normal and KSHV-infected and -transformed cells. A The glycolysis is tightly linked to the oxygen level in normal cells. Under normoxia, the glucose is metabolized to pyruvate that fuels the TCA cycle and is coupled with oxidative phosphorylation to generate copious ATP. Under hypoxia, the glucose is metabolized to pyruvate, which is converted to lactate. B KSHV-encoded miRNA cluster and vGPCR induce the aerobic glycolysis in short-term KSHV-infected endothelial cells by upregulating HIF1α and inhibiting mitochondria. C KSHV-encoded miRNA cluster and vFLIP suppress the glycolysis and oxidative phosphorylation by NF-κB-mediated downregulation of GLUT1 and GLUT3