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Table 1 Combination index (CI) values for propranolol and T1012G combination for HGC-27 gastric cancer cell lines

From: β-adrenergic receptor inhibition enhances oncolytic herpes virus propagation through STAT3 activation in gastric cancer

 

Propranolol (40 μM) + T1012G (0.01MOI)

Propranolol + T1012G

Propranolol → T1012G

CIa

1.023 ± 0.035

0.549 ± 0.017

Combination effect

Nearly additive ± 

Synergism+++

 

Propranolol (40 μM) + T1012G (0.05MOI)

Propranolol + T1012G

Propranolol → T1012G

CIa

0.944 ± 0.008

0.624 ± 0.042

Combination effect

Nearly additive ± 

Synergism+++

 

Propranolol (40 μM) + T1012G (0.1MOI)

Propranolol + T1012G

Propranolol → T1012G

CIa

0.829 ± 0.130

0.540 ± 0.049

Combination effect

Moderate synergism++

Synergism+++

  1. aCombination index [±: nearly additive (CI 0.90–1.10); +: slight synergism (CI 0.85–0.90); ++: moderate synergism (CI 0.70–0.85); +++: synergism (CI 0.30–0.70)] (55) The CI value of combination models were measured by Chou-Talalay method where CI value quantitatively defines synergism (CI < 1), additive effect (CI = 1) and antagonism (CI > 1)
  2. Data are presented as mean ± SEM, P < 0.05 (unpaired t-test)
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Cell & Bioscience

ISSN: 2045-3701

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