Fig. 2

Propranolol enhanced the propagation of oncolytic herpes simplex virusT1012G in vitro. A Viral replication assay was applied to measure the propagation of T1012G (0.1 MOI) in HGC-27 either co-treated or pre-treated or post-treated by propranolol (40 μmol/l). The titer of T1012 was measured 24 h and 48 h after infection. B T1012G (0.01 MOI) was pre-treated by propranolol (40 μmol/l) in HGC-27 for 12, 24 or 48 h. The titer of virus was measured 48 h after infection. Data are presented as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 vs. T1012 only (Tukey test for multiple comparisons)