Fig. 1

In vivo deletion of Stat3 in mesenchymal progenitors. A Genotyping of Stat3f/f; Prx1-Cre mice and Stat3f/+ mice tail DNA. DNA ladder: 50Â bp. B Protein were extracted from P0 forelimbs. Western blot analysis revealed significant decrease of Stat3 protein expression in Stat3 CKO compared with control. C IHF staining showed the loss of Stat3 expression in bone tissues on Stat3 CKO (ulna section of P0 mice)