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Fig. 3 | Cell & Bioscience

Fig. 3

From: The hepatic senescence-associated secretory phenotype promotes hepatocarcinogenesis through Bcl3-dependent activation of macrophages

Fig. 3

The hepatocyte SASP induces activation of macrophages that participate in hepatocarcinogenesis. a Representative image of HE stained liver in the indicated groups. Bars, 100 µm. b, c IHC staining and relative quantification of CD68, iNOS, and CD163 in liver tissues at different time points. Bars, 100 µm. d Schematic diagram of macrophage depletion by GdCl3 in DEN-CCl4-treated mice. e Representative image showing liver morphology of different groups at month 6, and the number of tumor nodules per liver was determined. f Representative imaging of HE-stained tissues in the indicated groups 5 months after HCC induction. Bars, 100 µm. g–i IHC staining and relative quantification of CD68, iNOS, and CD163 in the liver tissues in the indicated groups at 5 months. Bars, 100 µm. n = 5 for each group. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001

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