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Fig. 5 | Cell & Bioscience

Fig. 5

From: Huaier polysaccharides suppress triple-negative breast cancer metastasis and epithelial-mesenchymal transition by inducing autophagic degradation of Snail

Fig. 5

LC3 expression is inversely correlated with that of Snail and prognosis in TNBC. a Expression of LC3 and Snail in 13 TNBC tissue samples is detected using mmunohistochemistry (mean  ±  SD, magnification  ×  10, scale bars: 50 μm, *P  <  0.05). b Expression of LC3, Snail, and E-cadherin in 13 TNBC tissue samples is detected using multicolor immune fluorescence (mean  ±  SD, magnification  ×  20, scale bars: 50 μm, magnification  ×  69.1, scale bars: 10 μm, *P  <  0.05). c, d The prognostic values of the mRNA expression ratio of Snail/LC3 in TNBC patients are analyzed (Kaplan–Meier plotter). A higher Snail/LC3 mRNA expression ratio is associated with poorer distance metastasis free survival (P  =  0.015) in the Gene-Chip Datasets (c) and poorer disease specific survival (P  =  0.04), disease free interval (P  =  0.029) and progression free interval (P  =  0.027) in TCGA RNA-Seq datasets (d). The top quartile was used as the cutoff value

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