Fig. 2

AnxA1 deletion does not alter the expression of FPR2, TRPV1 and other nociceptors. a Representative images of double immunofluorescent staining and b Venn diagram of the percentages of FPR2 positive and TRPV1 positive neurons in DRG sections from AnxA1^−/− mice and WT littermates labeled for FPR2 and TRPV1 as indicated. Scale bar, 100 μm. c Representative western blots band images and the quantification of the indicated proteins d ANXA1 (AnxA1^−/− versus control group, P = 0.45, Student’s t-test. n = 6 in control group, n = 6 in AnxA1^−/− group), and e TRPV1 AnxA1^−/− versus control group, P = 0.32, Student’s t-test. n = 6 in WT group, n = 6 in AnxA1^−/− group) in DRG tissues between AnxA1^−/− mice and control littermates. f Representative band images and the quantification of other nociceptors such as g TRPA1 and h TRPM8 in L4-6 DRG tissues between AnxA1^−/− mice and control littermates (AnxA1^−/− versus control, P = 0.82, P = 0.85, Student’s t-test. n = 6 in control group, n = 6 in AnxA1^−/− group). The relative density of the protein band image in control group was normalized to 1. All data are represented as mean ± SD