Fig. 1
The role of H19 and its targets in CH-related pathophysiological processes and the potential mechanisms. AMPK adenosine 5′-monophosphate (AMP)-activated protein kinase, CaMKIIδ Ca2+/calmodulin-dependent protein kinase IIδ, CN calcineurin, CTGF connective tissue growth factor, DUSP5 dual-specificity phosphatase 5, E2F1 E2F transcription factor 1, EZH2 enhancer of zeste homolog 2, FADD fas-associated protein with death domain, HIF-1α hypoxia-inducible factor 1α, ICAM-1 intercellular adhesion molecule 1, JNK jun n-terminal kinases, KDM3A Lysine (K)-specific demethylase 3 A, MDM2 mouse 3T3 cell double minute 2, NFAT nuclear factor of activated T cell, PA2G4 proliferation-associated protein 2G4, PRC2 polycomb suppression complex 2, RIPK receptor-interacting serine/threonine-protein kinase 1 and 3, STAT3 signal transducer and activator of transcription 3, VCAM-1 vascular cell adhesion molecule 1, VDAC1 voltage-dependent anion channel 1, YB-1 Y-box-binding protein-1