Fig. 3

Phenotype and function of circulating MAIT cells in patients with alcoholic and mixed cirrhosis compared with healthy controls. A Representative dot plot of CD69. Comparison of CD69 on peripheral mucosal-associated invariant T (MAIT) cells in alcoholic liver disease (n = 20), mixed cirrhosis (n = 16), and healthy control (n = 47) (F = 7.418, p = 0.001). B Representative intracellular cytokine staining of MAIT cells from healthy control (HCs) and patients with alcoholic cirrhosis. Comparison of IL-17A, IFN-γ, TNF-α levels between HC (n = 14–17) and patients with alcoholic cirrhosis (n = 9–12). C Cytolytic capacity profile of MAIT cells in the blood from HCs and patients with alcoholic cirrhosis. Comparison of Granzyme B and perforin between HC (n = 11–12) and alcoholic cirrhosis (n = 10–11). Data were analyzed using the analysis of variance (ANOVA) test, LSD test, and two-sample t-test. (*p < 0.05; **p < 0.01; NS. p > 0.05)