Fig. 1From: Potential of helper-dependent Adenoviral vectors in CRISPR-cas9-mediated lung gene therapySchematic presentation of four strategies of Cas9-mediated permanent gene correction. Mutant alleles of the CFTR gene can be corrected by integration of a copy of the wild-type gene through homology directed repair or homology independent targeted integration and microhomology-mediated end joining as well as base editingBack to article page