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Fig. 5 | Cell & Bioscience

Fig. 5

From: Current insights into the implications of m6A RNA methylation and autophagy interaction in human diseases

Fig. 5

Effects of m6A-autophagy interaction in cancer progression. A HIF-1α induced YTHDF1 expression promotes ATG2A and ATG14 translation. Subsequently, autophagy is activated, which could promote HCC progression. B m6A provides stability to UBE2C transcripts, which could inhibit autophagy. Consequently, the proliferation, clonal expansion, and invasive growth of NSCLC are promoted. C IGF2BP2 mediated increased stability of MYC mRNA promotes glycolysis and cancer cell proliferation in CRC. D Autophagy-mediated upregulation of FTO could increase the stability of PD-1, CXCR4, SOX10 transcripts and which can promote the progression of melanoma

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Cell & Bioscience

ISSN: 2045-3701

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