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Table 4 Differentially spliced genes in somatostatin-positive cells

From: Changes to the identity of EndoC-βH1 beta cells may be mediated by stress-induced depletion of HNRNPD

A

Location of splice event

Gene symbol

Exon Splicing Index

Exon p-val

Exon event name

Exon event score

Exon 7/8

DUS4L

− 4.02

0.0082

Alternative 3ʹ acceptor site

0.2

Exon 6/6

CLIC4

5.34

0.0015

Alternative 5ʹ donor site

0.2

3ʹ end of exon 1/1

RNU5B-6P

− 3.93

0.0087

Alternative 5ʹ donor site

0.2

Exon 11/11

DBNL; MIR6837

− 4

0.0049

Alternative 5ʹ donor site

0.21

Exon 7/7

NDUFS3

− 4.38

5.35E−05

Alternative 5ʹ donor site

0.21

Exon 6/6

ARHGDIB

4.46

0.0077

Alternative 5ʹ donor site

0.21

Exon 20/24

GTF2IP1

4.64

9.32E−05

Alternative 3ʹ acceptor site

0.21

Exon 3/6

TRIM64C

5.18

0.0089

Alternative 3ʹ acceptor site

0.21

Intron 4/12

NFKBIZ

5.34

0.0028

Alternative 5ʹ donor site

0.21

Exon 1/3

VAX1

9.05

0.0038

Alternative 3ʹ acceptor site

0.21

Intron 8/15

CARF

− 2.71

0.0014

Intron retention

0.21

Exon 6/6

HMGN1

7.78

0.0017

Alternative 3ʹ acceptor site

0.21

Intron 11/36

NBPF12

2.68

0.0023

Intron retention

0.21

Intron 6/35

NUP160

3.74

0.0023

Intron retention

0.22

Intron 2/9 or

Intron 1/8

AP3M2

4.34

0.0051

Intron retention

0.22

Alternative 3ʹ acceptor site

COL28A1

4.29

0.0068

Alternative 3ʹ acceptor site

0.23

Intron 12/21

ACAP1

3.01

0.0042

Intron retention

0.23

Exon 3/5

HINT2

2.95

0.0004

Intron retention

0.24

Intron 11/12

SEPT7P2

− 3.01

0.0089

Intron retention

0.24

Intron 3/8 or

Intron 2/7

ACTG2

− 3.09

0.005

Intron retention

0.24

Intron 6 in exon 7/16

SLC9A8

14.06

0.0043

Intron retention

0.25

Intron1 in exon 1/5

CUTA

3.34

0.0059

Intron retention

0.27

Intron 14/29 or 30

TRAPPC11

− 10.49

0.0014

Intron retention

0.32

Intron 6/8

STAG3L3; STAG3L2

3.78

0.0002

Intron retention

0.32

Intron 3/11 or

Intron 2/10

ACVR2A

5.65

0.0077

Intron retention

0.33

Intron 5/8

PRKRIP1

4.3

0.0019

Intron retention

0.36

Intron 5/12 or

Intron 7/13 or

Intron 4/9

PHYKPL

20.83

0.0014

Intron retention

0.36

Intron 12/18 or

Intron 13/19

MPP3

− 4.93

0.0013

Intron retention

0.37

Intron 4/7

GLT1D1

− 4.16

0.0004

Intron retention

0.37

B

GO biological process complete

Fold enrichment

Raw p value

Positive regulation of transcription from RNA polymerase II promoter in response to calcium ion (GO:0061400)

> 100

0.00

Positive regulation of NAD + ADP-ribosyltransferase activity (GO:1901666)

> 100

0.01

Regulation of NAD + ADP-ribosyltransferase activity (GO:1901664)

> 100

0.01

Post-embryonic camera-type eye morphogenesis (GO:0048597)

> 100

0.01

Penile erection (GO:0043084)

> 100

0.01

Cellular response to redox state (GO:0071461)

> 100

0.01

Pyrimidine dimer repair by nucleotide-excision repair (GO:0000720)

> 100

0.01

Sertoli cell proliferation (GO:0060011)

> 100

0.01

Constitutive secretory pathway (GO:0045054)

> 100

0.01

Mesenchyme migration (GO:0090131)

> 100

0.01

tRNA dihydrouridine synthesis (GO:0002943)

> 100

0.01

Negative regulation of trophoblast cell migration (GO:1901164)

> 100

0.01

Sperm ejaculation (GO:0042713)

> 100

0.01

Post-embryonic eye morphogenesis (GO:0048050)

> 100

0.01

Post-embryonic camera-type eye development (GO:0031077)

> 100

0.01

Negative regulation of neuroblast proliferation (GO:0007406)

99.01

0.01

Positive regulation of activin receptor signaling pathway (GO:0032927)

99.01

0.01

Positive regulation of T-helper 17 cell differentiation (GO:2000321)

99.01

0.01

Pyrimidine dimer repair (GO:0006290)

88.01

0.01

Post-embryonic animal organ morphogenesis (GO:0048563)

88.01

0.01

Positive regulation of T-helper 17 type immune response (GO:2000318)

79.21

0.01

  1. (A) Differentially spliced genes: This table shows the 29 most differentially spliced genes with exon p value of <p = 0.01, splicing index of > 2 or < −2 and exon event score of > 02. Splicing index is used as a measure to detect alternative splicing events where a value larger or smaller than one indicates the presence of alternative splicing. Exon event score is a further measure of an aberrant or alternative splicing events. (B) GO terms analysis: The table gives the Gene Ontology (GO) biological processes pathway, the fold enrichment of differentially-regulated genes within that pathway and the p value for significance for biological processes pathways that contain significantly more differentially spliced genes in somatostatin-positive cells than would be expected by chance