Fig. 7

In vitro and in vivo inhibitory activity of GL25E against authentic HCoV infection. Inhibition of GL25E on in vitro infection by authentic SARS-CoV-2 (a), HCoV-OC43 (b) and HCoV-229E (c). Inhibition of GL25E on in vivo infection by authentic HCoV-OC43, as shown by the changes of body weight (d) and survival rate (e) of mice treated with PBS and GL25E 0.5 h prior to viral challenge, or the changes of body weight (f) and survival rate (g) of mice treated with PBS and GL25E 0.5 h after HCoV-OC43 challenge, or the changes of body weight (h) and survival rate (i) of mice treated with GL25E at indicated time before or after viral challenge. Each sample was tested in triplicate, and the experiment was repeated at least twice. Data from a representative experiment are presented as means ± SD