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Fig. 4 | Cell & Bioscience

Fig. 4

From: A bivalent protein targeting glycans and HR1 domain in spike protein potently inhibited infection of SARS-CoV-2 and other human coronaviruses

Fig. 4

The mechanism of action of GL25E in inhibiting SARS-CoV-2 infection. The binding of GL25E to S1 subunit (a) and RBD (b) as measured by ELISA. The effect of mannose on the binding of GL25E to S1 subunit (c) and RBD (d). The effect of GL25E on the binding of S1 subunit (e) and RBD (f) to ACE2. The effect of GL25E (g) and GRFT (h) on 6-HB formation. The inhibition of GL25E on SARS-CoV-2 S-mediated cell–cell fusion (i). Each sample was tested in triplicate and the data were presented as means ± SD. Significant difference between two groups was analyzed using the unpaired two-tailed Student’s -t test. **P < 0.01; ***P < 0.001; ****P < 0.0001

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Cell & Bioscience

ISSN: 2045-3701

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