Fig. 7

Effect of FTVII-modified BMSCs on the ENS remodeling in diabetic mice. A–D GFP-labeled unmodified and FTVII-modified BMSCs (green) and GFAP (red) were jointly immunostained in the freshly intermuscular plexus tissues of colon. The nuclei were labeled with DAPI (blue). E The partial enlargement images of the DM + F-BMSCs group. F The protein expression of GDNF in the colon tissues was examined by immunoblotting. G The statistics result of GDNF protein expression in the colon tissues. Control: the control C57 mice; DM: diabetic mice; DM + BMSCs: diabetic mice injected with unmodified BMSCs; DM + F-BMSCs: diabetic mice injected with FTVII-modified BMSCs. These results are representative of at least three times independent experiments. Results were expressed as mean ± SD, *P < 0.05, **P < 0.01, NS no significance