Fig. 5
Intestinal epithelium-specific deletion of PRMT1 increases Goblet cells in the crypt. The proximal and distal small intestine of 8-week-old adult wild type (PRMT1fl/flVil-Cre−/−) or PRMT1 knockout (PRMT1fl/flVil-Cre+/−) mice were sectioned and stained with Alcian Blue to detect the goblet cells (A). The number of Goblet cells in the villi and crypts were counted from multiple sections per animal and graphed (B, C). Note that Goblet cell number was increased in the crypt but not villus of both distal and proximal intestine in PRMT1 knockout mice. For both PRMT1 knockout and control wild type littermates, n = 4. ***p < 0.001. ns no significant