Fig. 2
Intestinal epithelium-specific deletion of PRMT1 alters the structural characteristics of adult intestine. A PRMT1 knockout does not affect absolute intestinal length. The length of the intestine was measured for 8-week-old adult wild type (PRMT1fl/flVil-Cre−/−) or intestinal epithelium-specific PRMT1 knockout (PRMT1fl/flVil-Cre+/−) mice. B PRMT1 knockout increases the relative length of the intestine normalized by body weight. The length of the intestine (cm) as in A was normalized against the body weight of the animals (grams). C–E PRMT1 knockout increases the crypt length. The intestine from 8-week-old wild type or PRMT1 knockout mice were dissected and stained with H&E staining (C) and the length of the villus (D) or crypt (E) were measured for both distal and proximal small intestine from multiple sections per animal. Note that the crypt length was increased in both distal and proximal small intestine. The villus length was not altered in the proximal small intestine and slightly decreased in the distal small intestine. For both PRMT1 knockout and control littermates, n = 4. *p < 0.05, **p < 0.01, ***p < 0.001. ns no significant