Fig. 7

Affected glucose homeostasis in JAZF1-Het mice fed with HFD. Eight-week-old males and females of both the JAZF1-Het-HFD (Het-HFD) and JAZF1-Cont-HFD (Cont-HFD) mice were fed with HFD for 8 weeks. After 8 weeks of HFD feeding, a, b GTT glucose levels were measured in males and females of both the JAZF1-Het-HFD and JAZF1-Cont-HFD mice after injecting the glucose (1.5 g/kg body weight, n = 8). c, d ITT glucose levels in male and female JAZF1-Het-HFD and JAZF1-Cont-HFD mice after injecting the insulin (2 U/kg body weight). The data presented by percent (%) of initial (0 min) glucose levels (n = 8). e Area under the curve (AUC) glucose levels in males and females of both the Het-HFD and Cont-HFD mice (n = 8), as determined by GTT and ITT glucose levels. The data is shown in the percentage (%) of control mice AUC glucose levels. f Serum insulin levels in 6 h fasted male and female of both the Het-HFD and the Cont-HFD mice after 8 weeks of HFD feeding (n = 6). All data are presented as mean ± SEM. *p < 0.05. GTT glucose tolerance test, ITT insulin tolerance test