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Fig. 3 | Cell & Bioscience

Fig. 3

From: JAZF1 heterozygous knockout mice show altered adipose development and metabolism

Fig. 3

JAZF1-Het mice showed a lower adipose tissue fat mass. JAZF1-Het (Het) and JAZF1-Cont (Cont) mice were fed with ND for 8 weeks starting at 8-week-old. a Relative JAZF1 mRNA expression in several tissues (eWAT, scWAT, liver, pancreas, BAT, and muscle) in JAZF1-Het and JAZF1-Cont mice (8-week-old, nĀ =Ā 5). After 8 weeks of ND feeding, b PPercent of organs weight (eWAT, scWAT, BAT, and liver) were measured to total body weight (nĀ =Ā 5). c Whole-body composition analysis was performed by micro-CT in JAZF1-Het and JAZF1-Cont mice. Green areas represent subcutaneous adipose tissue (SAT) mass; the red area represents visceral adipose tissue (VAT) mass. SAT and VAT masses are presented as percentages to total body volume mass (nā€‰=ā€‰5). d Lean mass is presented as a percentage of total body volume massĀ āˆ’Ā total adipose tissue mass (nā€‰=ā€‰5). e H&E staining of eWAT and scWAT in JAZF1-Het and JAZF1-Cont mice fed with ND for 8 weeks. Scale bar, 100Ā Āµm. Quantification of f eWAT and g scWAT adipocyte diameters frequency in both the JAZF1-Het and the JAZF1-Cont mice fed with ND for 8 weeks (left panel). Mean adipocyte diameter was also quantified by the calculation of each single adipocyte diameter (right panel). The diameters in eWAT and scWAT were quantified in three random images from each mouse (nā€‰=ā€‰6). All data are presented as meanā€‰Ā±ā€‰SEM. *pā€‰<ā€‰0.05, **pā€‰<ā€‰0.01, and ***pā€‰<ā€‰0.001. eWATĀ epididymal white adipose tissue, scWATĀ subcutaneous adipose tissue, BATĀ brown adipose tissue

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