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Fig. 8 | Cell & Bioscience

Fig. 8

From: Synapse-specific Lrp4 mRNA enrichment requires Lrp4/MuSK signaling, muscle activity and Wnt non-canonical pathway

Fig. 8

Inhibition of Lrp4 expression by ROCK inhibitor RKI-1447. a No effect of canonical Wnt signaling molecules on Lrp4 mRNA levels. n > 4, one-way ANOVA. b Reduced Lrp4 mRNA by RKI-1447. Myotubes were treated with RKI-1447 for 8 h. n > 3. c, d Reduced Lrp4 protein in RKI-1447-treated C2C12 myotubes. c Representative blots. d Quantification of data in c. **p = 0.0016, n = 3, unpaired t-test. e Inhibition of Lrp4 expression in Wnt3-expressing C2C12 myotubes. **p = 0.0047, ****p < 0.0001, n ≥ 6, one-way ANOVA

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Cell & Bioscience

ISSN: 2045-3701

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