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Fig. 4 | Cell & Bioscience

Fig. 4

From: Synapse-specific Lrp4 mRNA enrichment requires Lrp4/MuSK signaling, muscle activity and Wnt non-canonical pathway

Fig. 4

A critical role of the transmembrane domain of Lrp4 for synaptic localization of Lrp4 β-gal. a–c Inability of ECD to restore β-gal synaptic localization in P0 mice. a Representative images. b Quantitative analysis of bandwidth. c Quantitative analysis of AChR clusters. d–f Wider distribution of Lrp4 β-gal clusters in adult mice. d Representative images. e Quantitative analysis of bandwidth. f Quantitative analysis of AChR clusters. g–i Ability of Lrp4-ΔICD to restore Lrp4 β-gal synaptic localization in adult mice. g Representative images. h Quantitative analysis of bandwidth. i Quantitative analysis of AChR clusters. ***p < 0.001, ****p < 0.0001, n ≥ 7 mice per group, unpaired t-test

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Cell & Bioscience

ISSN: 2045-3701

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