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Table 1 Lysine crotonyltranferases and their histone and non-histone substrates

From: Emerging roles of non-histone protein crotonylation in biomedicine

Family Enzyme name Substrates and modified lysine residues  
Histone References Non-histone References
p300/CBP family p300, CBP H3K18 [31] NPM1, DDX5 [17]
MYST family hMOF H3K4, H3K9, H3K18, H3K23, H4K8, and H4K12 [32] NPM1 [17]
  Esa1 H4K5, H4K8, H4K12, and H4K16 [33] N/A N/A
GNAT family GCN5 H3K9, K3K14, and H3K18A [33] N/A N/A
  PCAF N/A N/A NPM1 [17]
  1. DDX5 DEAD-box helicase 5, Esa1 essential Sas2-related acetyltransferase 1, GCN5 general control nonrepressed-protein 5, GNAT GCN5-related N-acetyltransferase, hMOF human males absent on the first, MYST Moz, Ybf2, Sas2, and Tip60, NPM1 nucleophosmin-1, N/A not available, PCAF P300/CBP-associated factor, P300/CBP P300/CREB-binding protein