Emerging roles of non-histone protein crotonylation in biomedicine

Cell & Bioscience

Table 1 Lysine crotonyltranferases and their histone and non-histone substrates

Family	Enzyme name	Substrates and modified lysine residues
Family	Enzyme name	Histone	References	Non-histone	References
p300/CBP family	p300, CBP	H3K18	[31]	NPM1, DDX5	[17]
MYST family	hMOF	H3K4, H3K9, H3K18, H3K23, H4K8, and H4K12	[32]	NPM1	[17]
	Esa1	H4K5, H4K8, H4K12, and H4K16	[33]	N/A	N/A
GNAT family	GCN5	H3K9, K3K14, and H3K18A	[33]	N/A	N/A
	PCAF	N/A	N/A	NPM1	[17]

DDX5 DEAD-box helicase 5, Esa1 essential Sas2-related acetyltransferase 1, GCN5 general control nonrepressed-protein 5, GNAT GCN5-related N-acetyltransferase, hMOF human males absent on the first, MYST Moz, Ybf2, Sas2, and Tip60, NPM1 nucleophosmin-1, N/A not available, PCAF P300/CBP-associated factor, P300/CBP P300/CREB-binding protein

ISSN: 2045-3701