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Fig. 7 | Cell & Bioscience

Fig. 7

From: Spermidine induces cytoprotective autophagy of female germline stem cells in vitro and ameliorates aging caused by oxidative stress through upregulated sequestosome-1/p62 expression

Fig. 7

Proposed model of the regulatory mechanism of SPD-induced cytoprotective autophagy. SPD initiated autophagy via PI3K/AKT/mTOR signaling pathway. As a downstream target of the AKT/mTOR pathway, p62 may be a target protein for anti-aging. SPD maybe upregulate Bcl-2 mRNA and inhibit apoptosis

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Cell & Bioscience

ISSN: 2045-3701

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