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Fig. 5 | Cell & Bioscience

Fig. 5

From: Spermidine induces cytoprotective autophagy of female germline stem cells in vitro and ameliorates aging caused by oxidative stress through upregulated sequestosome-1/p62 expression

Fig. 5

SPD changes expression of autophagy-related genes and pathways in FGSCs. A Hierarchical clustering shows differentially expressed mRNA patterns between the control and SPD-treated groups. B Volcano plot of differentially expressed mRNAs. C Differentially expressed mRNAs are related to genes involved in the PI3K/AKT pathway. The qRT-PCR results are consistent with changes in the transcriptome profile (Pā€‰<ā€‰0.05). ***Pā€‰<ā€‰0.001 compared with controls. Note that one of the differentially expressed mRNAs is Bcl-2, which can inhibit cell death. D GO analysis of RNA-seq data. The top 17 significantly enriched biological processes are shown. E KEGG pathway analysis of RNA-seq data. The top seven enriched pathways are shown. Con control

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