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Fig. 5 | Cell & Bioscience

Fig. 5

From: CpG oligodeoxynucleotides attenuate RORγt-mediated Th17 response by restoring histone deacetylase-2 in cigarette smoke-exposure asthma

Fig. 5

CpG-ODN and BUD synergistically regulate the interplay of HDAC2, RORγt and IL-17 A, orchestrating the inflammatory response in HBE cells. Th2-associated cytokines (a, c) examined by ELISA, and relative mRNA levels of Th2 cytokines in lung tissue specimens from mice (b, d), determined by qRT-PCR. Th17-associated cytokines (e) assessed by ELISA, and relative mRNA levels of Th2 cytokines in lung tissue samples from mice (f), evaluated by qRT-PCR.Immunoblot was carried out for assessing the protein amounts of HDAC2 (g) and RORγt in HBE cells, with GAPDH as a loading control; HDAC2/GAPDH (g) and RORγt/GAPDH (h) ratios were determined. Statistical significance denoted:*, #p < 0.05, **,##p < 0.01. * versus the vehicle control group; # versus the indicated group

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Cell & Bioscience

ISSN: 2045-3701

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