Table 4 Kidney-specific intervention targeting genes for improving renal microcirculation
Setting | Intervention | Mechanism | Effects | References |
|---|---|---|---|---|
Renal interstitial fibrosis (UUO model) | Protein phosphatase 2A knockout | Preserved density of peritubular capillaries and ameliorated renal EndoMT level | Prevented renal fibrosis | [109] |
Renal interstitial fibrosis (UUO model) | Deletion of the Stromal Cell Marker CD248 (Endosialin) | Inhibited microvascular rarefaction through modulation of pericyte and stromal cell function | Ameliorated renal fibrosis | [110] |
Chronic kidney disease (Ang-II induced renal injury) | Deletion of heparinbinding EGF-like factor (HB-EGF) | Preserved endothelial integrity and reduced inflammation in the perivascular area | Ameliorated renal injury | [114] |
Renal interstitial fibrosis (UUO model) | Thrombospondin-1 (TSP-1) gene silencing | Increased PTC density and ameliorate hypoxia | Prevented renal fibrosis | [115] |
Diabetic nephropathy (db/db model of DN) | lncRNA-MALAT1 knockout | Repressed endothelialto-mesenchymal transition via targeting miR-145/ZEB2 axis | Inhibited HGinduced fibrosis | [117] |