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Table 4 Kidney-specific intervention targeting genes for improving renal microcirculation

From: The renal microcirculation in chronic kidney disease: novel diagnostic methods and therapeutic perspectives

Setting Intervention Mechanism Effects References
Renal interstitial fibrosis (UUO model) Protein phosphatase 2A knockout Preserved density of peritubular capillaries and ameliorated renal EndoMT level Prevented renal fibrosis [109]
Renal interstitial fibrosis (UUO model) Deletion of the Stromal Cell Marker CD248 (Endosialin) Inhibited microvascular rarefaction through modulation of pericyte and stromal cell function Ameliorated renal fibrosis [110]
Chronic kidney disease (Ang-II induced renal injury) Deletion of heparinbinding EGF-like factor (HB-EGF) Preserved endothelial integrity and reduced inflammation in the perivascular area Ameliorated renal injury [114]
Renal interstitial fibrosis (UUO model) Thrombospondin-1 (TSP-1) gene silencing Increased PTC density and ameliorate hypoxia Prevented renal fibrosis [115]
Diabetic nephropathy (db/db model of DN) lncRNA-MALAT1 knockout Repressed endothelialto-mesenchymal transition via targeting miR-145/ZEB2 axis Inhibited HGinduced fibrosis [117]