Skip to main content

Table 3 Cell-based therapy for improving renal microcirculation

From: The renal microcirculation in chronic kidney disease: novel diagnostic methods and therapeutic perspectives

Setting Intervention Mechanism Effects references
Renal interstitial fibrosis (UUO model) Bone marrowderived endothelial progenitor cells (BM-EPCs) Increased the number of capillary density Alleviated interstitial fibrosis [97]
Renal interstitial fibrosis (UUO model) Adipose-derived mesenchymal stemcells (AMSCs) Improved renal microcirculation through PI3K/Akt/eNOS signaling pathway and inhibited the EndMT process Inhibited the kidney fibrogenesis [101]
AKI (ischeamia/reperfusion I/R model) Human adipose stromal cells (hASCs) Decreased inflammation and preserved peritubular capillaries Improved recovery from I/R- induced injury and chronic kidney injury [102]
AKI (ischeamia/reperfusion I/R model) Bone marrow mesenchymal stromal cells (BMSCs) Protected microvasculature and strongly suppressed fibrosis via the effects of vasoprotective cytokines Suppressed progressive fibrosis in kidney diseases [104]
Chronic renal failure (adenine induced CRF model) BMSCs Increased the glomerular capillaries density and promoted the secretion of VEGF via activating PI3k-Akt signaling pathway Improved renal function [105]
Renal interstitial fibrosis (unilateral ureteral obstruction UUO model) Human amniotic fluid-derived stem cells (hAFSCs) increased in microvascular density and relieve hypoxia Alleviated interstitial fibrosis alleviated interstitial fibrosis [106]