Setting | Intervention | Mechanism | Effects | references |
---|---|---|---|---|
Renal interstitial fibrosis (UUO model) | Bone marrowderived endothelial progenitor cells (BM-EPCs) | Increased the number of capillary density | Alleviated interstitial fibrosis | [97] |
Renal interstitial fibrosis (UUO model) | Adipose-derived mesenchymal stemcells (AMSCs) | Improved renal microcirculation through PI3K/Akt/eNOS signaling pathway and inhibited the EndMT process | Inhibited the kidney fibrogenesis | [101] |
AKI (ischeamia/reperfusion I/R model) | Human adipose stromal cells (hASCs) | Decreased inflammation and preserved peritubular capillaries | Improved recovery from I/R- induced injury and chronic kidney injury | [102] |
AKI (ischeamia/reperfusion I/R model) | Bone marrow mesenchymal stromal cells (BMSCs) | Protected microvasculature and strongly suppressed fibrosis via the effects of vasoprotective cytokines | Suppressed progressive fibrosis in kidney diseases | [104] |
Chronic renal failure (adenine induced CRF model) | BMSCs | Increased the glomerular capillaries density and promoted the secretion of VEGF via activating PI3k-Akt signaling pathway | Improved renal function | [105] |
Renal interstitial fibrosis (unilateral ureteral obstruction UUO model) | Human amniotic fluid-derived stem cells (hAFSCs) | increased in microvascular density and relieve hypoxia | Alleviated interstitial fibrosis alleviated interstitial fibrosis | [106] |