Skip to main content

Table 1 The origin, morphology, genetic mutation, tumorigenic capability, and metastatic potential of OS cell lines

From: Research models and mesenchymal/epithelial plasticity of osteosarcoma

Cell line Origin Morphology Gene mutation Days to form 1.5–2 cm3 tumor Meta
rate (%)
Refs.
Tumor suppressor Oncogene
CDKN2A TP53 RB1 PTEN BRAF KRAS
HOS OS of a 13-y-o girl E m/m m/m w/w w/w w/w w/w No tumor in 8 weeks 0% [58, 64]
143B HOS cells, transformed by KRAS Mixed E/F m/m m/m w/w w/w w/w m/w 27 100% [64, 69]
MNNG HOS cells, induced by MNNG Mixed E/F m/m m/m w/w w/w w/w w/w 32 100% [64, 66, 70]
SaOS-2 OS of a 11-y-o girl E w/w m/m m/m w/w w/w w/w 95 100% [62, 63]
SaOS-LM7 Lung Meta from SaOS-2 cells in mouse tibia E w/w m/m m/m w/w w/w w/w 65 100% [71]
MG-63 Fibroblastic OS of a 14-y-o boy F m/m m/m w/w w/w w/w w/w 170 0% [59]
U-2 OS Sarcoma in tibia of a 15-y-o girl E w/w w/w w/w w/w w/w w/w No tumor in 150 days 0% [60, 61, 72]
K7 (K8, …, K12) Spontaneous OS in BALB/c mouse O NA NA NA NA NA NA NA 33.3% (K12) [37, 38, 45]
K7M2 Lung meta
From
K7 cells in mouse tibia
O NA NA NA NA NA NA 30 days to reach 0.8 cm3 93.3% [36, 37, 39, 40, 45]
Dunn Spontaneous OS from C3H/HeN mouse tail E NA NA NA NA NA NA 25 100% [42, 45]
UMR 106-01 32P-induced tumor in rat E NA NA NA NA NA NA 25 days to reach 0.15 cm3 100% [32, 47]
D-17 Lung Meta of OS in a 11-y-o female poodle E NA NA NA NA NA NA No tumor in 79 days NA [53]
  1. m/m, mutant/mutant homozygous; w/w, wild type/wild type normal alleles; m/w, mutant/wild type heterozygous; NA, not available; E, epithelial; F, fibroblast; O, osteoblast; Meta, metastasis