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Table 2 Clinical signs and PEDV shedding of pigs challenged with the highly virulent icPC22A (1–9 dpc)

From: Crucial mutation in the exoribonuclease domain of nsp14 of PEDV leads to high genetic instability during viral replication

Group

No. of pigs

Mortality rate

Severe diarrhea rate

Onset of severe diarrhea (dpc)

Duration of severe diarrhea (days)

Duration of diarrhea (days)

Peak mean RNA shedding titer (log10 copies/mL)

E191A-P1

3

0 (0/3)

100% (3/3)

4.67 ± 1.15

2.33 ± 0.58 a

5.33 ± 1.15 a

9.03 ± 0.44 a

Mock

5

40% (2/5)

100% (5/5)

4.00 ± 0.00

6.33 ± 0.470 b

8.00 ± 0.00 b

10.43 ± 0.87 b

  1. dpc: days post challenge
  2. Fecal scores of 2 and 3 were considered as moderate diarrhea and severe diarrhea, respectively
  3. a, b: Different letters denote significant difference between groups (p < 0.05)